Well this is kind of an old thread but only a dozen down on the first page (slow subforum I guess).
I got this game for Christmas, got about 6 hours into it so far [note to self: don't get an tough-to-tear-away-from game when you're expecting the in-laws for the holidays because it is just girls going blah blah blah and really tough to pay attention to the dialogue and even worse to try to explain to your mother-in-law why you're tying a hooker to the railroad tracks] and really am enjoying it. Fast travel is for fools, almost every trip I've taken "manually" as resulted in something interesting happening.