Do you guys really think its the card? I find it weird that I'm now getting no mobo/mouse/etc. power after reinstalling the GPU. But I do have another card I can test it with at my parents house, so I'll grab that tomorrow and try it. Luckily I just got my tax return back so I'll probably end up buying a 9800 GTX+ when this is all said and done, but I'll have to replace the PSU going that route anyway so I'll try that first.

The card itself is maybe 6-7 months old, and never caused an issue before. I've played Crysis on it at max with no problems. No overheating issues, power failures, anything. The entire computer itself is actually around the same age.